Nucleoside Transporters
Nucleoside Transporters
Nucleoside transporters (NTs) are a class of transmembrane proteins responsible for mediating the transmembrane transport of nucleosides and nucleoside analogs. They are widely expressed in mammalian cells and are classified into two major families based on their transport mechanisms and substrate specificities: equilibrative nucleoside transporters (ENTs/SLC29) and concentrative nucleoside transporters (CNTs/SLC28). ENTs have four subtypes (hENT1-4), which passively transport nucleosides through concentration gradients. CNTs have three subtypes (hCNT1-3), which actively uptake nucleosides dependent on sodium ion gradients.
Nucleoside transporters can be used in research on cardiovascular diseases, cancer, and viral diseases[1][2][3].
References:
- [1]. Playa H, et al. Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorg Med Chem Lett. 2014 Dec 15;24(24):5801-5804. [Content Brief]
- [2]. Yamamoto T, et al. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters[J]. European journal of pharmacology, 2007, 557(1): 1-8. [Content Brief]
- [3]. Choudhuri S, et al. The biology of nutrients: genetic and molecular principles[M]//Nutraceuticals. Academic Press, 2016: 209-225.
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Nucleoside Transporters Related Products (18)
Related Products (18)
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Dilazep dihydrochloride
0 ImagesDilazep dihydrochloride is a GATA2 inhibitor and an hENT1-mediated nucleoside transport inhibitor. Dilazep dihydrochloride acts by blocking GATA2 chromatin recruitment and DNA binding, reducing GATA2 thermal stability, and inhibiting AR, c-MYC, the cell cycle, DNA replication/repair, and metastatic transcriptional programs; it also inhibits Adenosine (HY-B0228) reuptake and cardiac adenosine uptake, enhancing adenosine-induced coronary vasodilation. Dilazep dihydrochloride can be used in research on atherosclerosis, ischemic heart disease, and castration-resistant prostate cancer.
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hENT4-IN-1
0 ImageshENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM.
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N6-(4-Hydroxybenzyl)adenosine
0 ImagesSynonyms: Para-topolin ribosideN6-(4-Hydroxybenzyl) adenosine (Para-topolin riboside) is an equilibrative nucleoside transporter 1 (ENT1) inhibitor and a selective agonist of adenosine A2a receptor (A2aR), and also exhibits activity against P2Y12 receptor. N6-(4-Hydroxybenzyl) adenosine reduces ethanol intake and preference, attenuates operant conditioning-induced ethanol place preference, decreases the value of ethanol-related rewards, and inhibits collagen-induced platelet aggregation. N6-(4-Hydroxybenzyl) adenosine can be used in studies related to alcohol use disorder.
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CNT2 inhibitor-1
0 ImagesCNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.
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EOS-984
0 ImagesEOS-984 is a macrocyclic diamine equilibrative nucleoside transporter 1 (ENT1) inhibitor. EOS984 inhibits ENT1 and ENT1-mediated nucleoside transport, restricting adenosine entry into cells via ENT1, thereby attenuating ATP-derived adenosine-mediated T cell immunosuppression and restoring primary human T cell proliferation. EOS984 can be used in research related to ENT1-mediated nucleoside transport, adenosine-related immunosuppression, and tumor immunity.
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A2AR-agonist-1
0 ImagesA2AR-agonist-1 is a potent A2AR agonist and ENT1 inhibitor with Ki of 4.39 and 3.47 for A2AR and ENT1.
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FPMINT
0 ImagesFPMINT is a potent, irreversible and non-competitive inhibitor of Equilibrative nucleoside transporters (ENTs), which is more selective to ENT2 than to ENT1. FPMINT plays an important role in uridine uptake.
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8MDP
0 ImagesCat. No.: HY-110104CAS No.: 29491-75-68MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC50 of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H3] uridine by K562 cells and K15NTD cells.
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Soluflazine
0 ImagesSoluflazine is a nucleoside transport inhibitor with anticonvulsant action. Soluflazine can be used as an antiepileptic agent.
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Dilazep dihydrochloride (Standard)
0 ImagesDilazep dihydrochloride (Standard) is the analytical standard of Dilazep dihydrochloride (HY-100957). This product is intended for research and analytical applications. Dilazep dihydrochloride is a GATA2 inhibitor and an hENT1-mediated nucleoside transport inhibitor. Dilazep dihydrochloride acts by blocking GATA2 chromatin recruitment and DNA binding, reducing GATA2 thermal stability, and inhibiting AR, c-MYC, the cell cycle, DNA replication/repair, and metastatic transcriptional programs; it also inhibits Adenosine (HY-B0228) reuptake and cardiac adenosine uptake, enhancing adenosine-induced coronary vasodilation. Dilazep dihydrochloride can be used in research on atherosclerosis, ischemic heart disease, and castration-resistant prostate cancer.
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KW-7158
0 ImagesKW-7158 is a putative afferent nerve inhibitor that can depress vesica-vascular reflexes in rats. KW-7158 is an inhibitor of nucleoside transporter-1 (ENT1/SLC29A1) and acts as an antagonist for overactive bladder (OAB).
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Dilazep
0 ImagesCat. No.: HY-100957ACAS No.: 35898-87-4Dilazep is a GATA2 inhibitor and an hENT1-mediated nucleoside transport inhibitor. Dilazep acts by blocking GATA2 chromatin recruitment and DNA binding, reducing GATA2 thermal stability, and inhibiting AR, c-MYC, the cell cycle, DNA replication/repair, and metastatic transcriptional programs; it also inhibits Adenosine (HY-B0228) reuptake and cardiac adenosine uptake, enhancing adenosine-induced coronary vasodilation. Dilazep can be used in research on atherosclerosis, ischemic heart disease, and castration-resistant prostate cancer.
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hENT4-IN-1 (Standard)
0 ImagesCat. No.: HY-110165RCAS No.: 949467-71-4hENT4-IN-1 (Standard) is the analytical standard of hENT4-IN-1 (HY-110165). This product is intended for research and analytical applications. hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM.
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dMeThPmR
0 ImagesCat. No.: HY-177747CAS No.: 1262032-37-0dMeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki = 0.3-0.98 μM). dMeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 133 μM) and hCNT3 (Ki = 32.7 μM). dMeThPmR can protect cells from the toxicity of nucleoside drugs. dMeThPmR can be used for the research of cancer.
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MeThPmR
0 ImagesCat. No.: HY-177746CAS No.: 1262032-38-1MeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki/sub> = 0.16-0.69 μM). MeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 360 μM) and hCNT3 (Ki = 4.7 μM). MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer.
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