Nucleoside Transporters
Nucleoside Transporters
Nucleoside transporters (NTs) are a class of transmembrane proteins responsible for mediating the transmembrane transport of nucleosides and nucleoside analogs. They are widely expressed in mammalian cells and are classified into two major families based on their transport mechanisms and substrate specificities: equilibrative nucleoside transporters (ENTs/SLC29) and concentrative nucleoside transporters (CNTs/SLC28). ENTs have four subtypes (hENT1-4), which passively transport nucleosides through concentration gradients. CNTs have three subtypes (hCNT1-3), which actively uptake nucleosides dependent on sodium ion gradients.
Nucleoside transporters can be used in research on cardiovascular diseases, cancer, and viral diseases[1][2][3].
References:
- [1]. Playa H, et al. Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorg Med Chem Lett. 2014 Dec 15;24(24):5801-5804. [Content Brief]
- [2]. Yamamoto T, et al. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters[J]. European journal of pharmacology, 2007, 557(1): 1-8. [Content Brief]
- [3]. Choudhuri S, et al. The biology of nutrients: genetic and molecular principles[M]//Nutraceuticals. Academic Press, 2016: 209-225.
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Nucleoside Transporters Related Products (13)
Related Products (13)
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Dilazep dihydrochloride
0 ImagesDilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides.
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hENT4-IN-1
0 ImageshENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM.
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N6-(4-Hydroxybenzyl)adenosine
0 ImagesSynonyms: Para-topolin ribosideN6-(4-Hydroxybenzyl) adenosine (Para-topolin riboside) is an equilibrative nucleoside transporter 1 (ENT1) inhibitor and a selective agonist of adenosine A2a receptor (A2aR), and also exhibits activity against P2Y12 receptor. N6-(4-Hydroxybenzyl) adenosine reduces ethanol intake and preference, attenuates operant conditioning-induced ethanol place preference, decreases the value of ethanol-related rewards, and inhibits collagen-induced platelet aggregation. N6-(4-Hydroxybenzyl) adenosine can be used in studies related to alcohol use disorder.
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CNT2 inhibitor-1
0 ImagesCNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.
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FPMINT
0 ImagesFPMINT is a potent, irreversible and non-competitive inhibitor of Equilibrative nucleoside transporters (ENTs), which is more selective to ENT2 than to ENT1. FPMINT plays an important role in uridine uptake.
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Soluflazine
0 ImagesSoluflazine is a nucleoside transport inhibitor with anticonvulsant action. Soluflazine can be used as an antiepileptic agent.
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NBTGR
0 ImagesNBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM.
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Dilazep dihydrochloride (Standard)
0 ImagesDilazep (dihydrochloride) (Standard) is the analytical standard of Dilazep (dihydrochloride). This product is intended for research and analytical applications. Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides.
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KW-7158
0 ImagesCat. No.: HY-116927CAS No.: 214764-26-8KW-7158 is a putative afferent nerve inhibitor that can depress vesica-vascular reflexes in rats. KW-7158 is an inhibitor of nucleoside transporter-1 (ENT1/SLC29A1) and acts as an antagonist for overactive bladder (OAB).
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Dilazep
0 ImagesCat. No.: HY-100957ACAS No.: 35898-87-4Dilazep is an inhibitor of adenosine uptake. Dilazep has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides.
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dMeThPmR
0 ImagesCat. No.: HY-177747CAS No.: 1262032-37-0dMeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki = 0.3-0.98 μM). dMeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 133 μM) and hCNT3 (Ki = 32.7 μM). dMeThPmR can protect cells from the toxicity of nucleoside drugs. dMeThPmR can be used for the research of cancer.
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MeThPmR
0 ImagesCat. No.: HY-177746CAS No.: 1262032-38-1MeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki/sub> = 0.16-0.69 μM). MeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 360 μM) and hCNT3 (Ki = 4.7 μM). MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer.
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